Growing up I was a huge RPG fan, but as I've gotten older it's been tougher finding a group that's on the same page that isn't overly frustrating with regard to scheduling. BUT, I do run a game club at my school and it's a great place for the misfits to come together and learn social skills and a lot more in a relaxed setting. I also do some board games in the classroom (Catan America, 1775: Rebellion, and may try Freedom this year).
I've always wanted to play Agricola and Le Havre personally. If you enjoy more intense games, Twilight Struggle (Cold War game) and Squad Leader (WW2 tactics game) are cool. Swords and Strongholds (by the company that makes the excellent RPGs Burning Wheel, Mouse Guard, and Torchbearer) looks neat too. I need to remember to push my girlfriend to try it with me sometime.
In game club I've discovered X-Wing (the space pilot equivalent of Imperial Assault - my coworker is obsessed and has a TON of the ships), Tummple (sort of a reverse jenga stacking game), Sushi Go, Cat Tower, then there's always the classic Settlers of Catan
There's a TMNT game that is due out soon that looks cool, but these games are so expensive, I find it hard to justify buying for personal enjoyment since it's tough to schedule hangs with friends.
I really would love to get more into Squad Leader personally and as a history nerd I love all the military strategy games the most.
EDIT: Sorry that some of these aren't proper board games, I think of any non-video games in a similar spirit of sitting around a table with friends.