Seeing the video of Holly's talk a few months ago made me really frustrated that I didn't bother going to Loop. It's especially intriguing to hear after seeing her (and her team) perform a couple of times.
I've also suffered from screen fatigue quite a bit.. after spending all day at work staring at pixels with a keyboard, looking at a screen is the last thing I want to do when I get home. This feeling was actually strong enough that I stopped making music on the computer altogether for a while. One of my favorite quotes on this topic comes from Roger Linn when talking about the Linnstrument (paraphrased a bit): "At a certain point in making music on the computer, I realized that I was actually playing, I was rolling a bar of soap around in front of the TV"
IMO, a lot of this boils down to pragmatism. I have a relatively small home studio, but I can't even imagine what a pain in the ass it would be to bring all of this stuff out for a live performance. Is it really worth bringing the OP-1 to live-trigger samples that I could use in some other way? Or bringing the keyboard synth so that I can play this one chord progression that only shows up for 30 seconds in one song?
There's definitely something to be said for the limitation of only working with the gear that you bring, but in many ways, sound preparation and studio treatment of loops (or shots) can yield results that you can't get any other way.
And I think there's also something to be said for the value of playing (instead of thinking, or science-ing) as a method of generating sounds: There isn't really anything that an OP-1 can do that a computer can't, but the OP-1 is immediately playable -- you don't have to think or science too hard to generate something appealing, that you can then throw into whatever you'd like into the computer for post-processing, etc.
I forget if I've talked about this on hear, but I've had this discussion of methods of performance and avenues of music consumption with a few people, and I think it's quite interesting. For (mainstream) theatrical performing arts, you have the medium of both film and stage. As an audience member, you don't judge the two on the same scale, and you expect different things from each type of performance. But, with theatrical performing arts, you have the stage theater, you have the movie theater, and then you have the home entertainment system as means of consumption. With music, there is no equivalent of the movie theater: either you're listening at home, or you're seeing something on the stage. So, why hasn't someone opened up a sound theater where it's expected that the "performance" is just hitting Play?