Of course. Primarily, I use it as a main control interface with my VST synths and effects. For instance, page 1 is currently handling filter cutoff, resonance, mod, decay, accent, wave form selection (on a knob push encoder), high pass filter, and volume for a VST synth across the top two rows. Third row is a push toggle for a distortion VST on/off / input gain on the knob, then drive, filter, and volume for the distortion. Fourth row are the three controls for Sausage Fattener, fatness / color / gain, with the fatness push encoder assigned to turning the effect on/off.
I have been using Replika XT and Trueverb quite a bit and to now have had those controls assigned to Monome Control faders, but as I am getting more into doing more Monome-centric music, I will be assigning them to pages on the Twister. It's a really handy device!