Critter & Guitari just announced they were releasing a new instrument later this year, the Organelle:
At the heart of the Organelle's sound engine is a robust computer that runs patches. A patch allows the instrument to take on different forms. Onboard hardware for sound input and output and mappable knobs, keys and buttons enable patches to synthesize, sample, effect and anything in between!
The Organelle™ ships with a set of common default patches, and new patches may be loaded from a USB drive. Simply select patches from our expanding community-driven online repository, transfer them to a USB drive, reinsert it in the Organelle™ and play!
Don't see the exact patch you need? You can create it yourself! Patches may be created and/or edited directly on the device as well as on a personal computer. Plug in a keyboard, mouse and monitor and begin customizing. The Organelle™ runs patches created in the powerful computer music programming environment Pure Data. (You can write patches in lower level languages too!)
Looks like it runs a full Linux environment with Pure Data on a 1GHz ARM processor - it has HDMI/USB out so you can plug in a keyboard/mouse/display and edit patches directly from there. Super intriguing, I'm looking forward to demos, but it seems likely that I'll pick one up! Although CV out would have been nice.