in theory, @wrl's mlr-like app rove just needs to be compiled for the organelle's cpu, assuming that it also has jack and a few other libraries ported and installed. rove is much more limited than mlr, but it has the essence of its functionality; i used it for all of my monome+linux shows.
rove is abandoned at this point, but there is a puredata port of mlr that the organelle could run as a native app. there was even a tutorial on how to create pd_mlr as an intro to monome+Pd patching on the old monome wiki. it's archived on the wayback machine.
@murray did a lot of work setting up a scripted environment that autostarts a bunch of headless apps (like rove) that would otherwise need config file editing, so some of that knowledge could be used with the organelle. a true port that can make use of the organelle's screen and other onboard capabilities would be the way to go. though at that point it would be easier to setup a <$500 linux laptop that does the same things.
i, too, want to get away from an obvious computer, but i haven't seen any standalone hardware, organelle or otherwise, that approaches the DSP horsepower and audio i/o needed for mlr-like functions. in modular, maybe the ER301, but that's also still in beta.