Yes, you can have either crow or Teletype talk to Just Friends and TXi. On crow try ii.jf.help() or ii.txi.help() to see available commands. With all of these modules wired together you can send commands either from crow or from Teletype, though using both at once is likely to cause issues possibly including module crashes. In particular crow will now print a warning if I2C lines are in use and crow didn’t initiate communication.
You can check out all the schematics and board files for bpcmusic’s TXb, seems very straightforward. Any kind of disturbance in the I2C bus definitely has the possibility to freeze Teletype, but if you think it is a very intermittent problem you might want to try the most recent beta firmware for Ansible and Teletype here, which includes a patch that limits the number of retries Teletype will do for I2C operations.
I think probably this is doable with newer Teletypes (black PCB), I’ve used a similar number of devices (though not 16n) with no trouble.