I own and love the APC 40 mkII. I also use a Push 2 but I think the APC is less fiddly to use in a performance scenario.
I used the APC for an hour long ambient set last year (in a remote location where I didn’t want to bring a lot of stuff) and this was more or less how I set it up:
I had my set broken down into two banks of 8 channels. The first bank of 8 channels were for stems/clips/sequences…playable elements of a track. I made sure everything could be broken down to fit into these 8 channels because I did a lot of live mixing, and this way the faders were never misrepresenting the state of the mix happening in Live’s mixer. Color coding your clips helps identify what’s what on the APC grid.
The next bank of 8 channels were for field recordings/transitions/one-shots. I left the top row of encoders in User mode, and assigned them to the levels of the 8 channels of this type. This way I could mix sounds of this type in and out using the encoders, while the grid and faders were still locked in to the tracks and mix.
As for adjusting track effects using the 8 effect encoders off to the side, careful planning and creating audio effects racks is key. I found it very helpful to set up some automation in certain clips that would reconfigure my effects racks for that particular track.
Did I glance over at my laptop? Yep, occasionally, but I probably didn’t need to. It was off to the side.