Given what a big change this is, I won’t be doing so for a long while (potentially never on my studio computer) since it breaks all sorts of things.
If you want to check your applications, you can follow these instructions:
I don’t know if that finds every library dependency for the apps, so it’s possible more stuff will break than what’s shown in System Information.
At minimum none of the drivers for my soundcards are fully 64bit, so that’s a big deal breaker just there. I also wonder if some of my older hardware (MOTU Traveller mk1) will get a driver update at all, in which case, that computer will never be updated past Mojave.
Thankfully I don’t have too many big dependencies beyond that, as I tend to go quite lean on the software I incorporate into my workflow. Other than the drivers, I’m a bit concerned about Shlisp/Fish, since I see “shlisp” in my list of 32bit apps.