yes it is.
Maybe.
First up you’ve got to consider pinout compatibility with the pcb - or you need to make your own carrier pcb to get the correct pinout.
Next you’d need to be sure the display in question is supported and the driver is part of the linux kernel being used. Monome is compiling that ssd1322 driver into their kernel
Then you’d need to change the dtoverlay for the display and Bob’s yer uncle.
I did this way back when with a wee ssh1106 display and it worked just fine. (but I had to recompile the fbtft driver and then the linux kernel numerous times
) But, the ssh1106 was also monochrome so it didnt work great with the grayscale needs of norns.