I did briefly and really enjoyed it. However, I found it really hard to keep up with the meta. After a while, it felt like I was getting my butt kicked because I didn’t want to spend money on decks or read endless discussions on synergies to build on.
Slay the Spire is mechanically quite different. It’s asymmetric, similar to something like Netrunner. There are three player characters to choose from, all of which have different decks and play styles. Additionally, the computer opponent does not have similar cards to you. Instead, each enemy has a static set of moves. Each type of enemy has attack patterns and unique debuffs to pay attention to.
There’s also a deckbuilding aspect similar to something like Dominion. Every time you start a game, your character starts with the same set of cards. You then find nodes on the map between battles that allow you to draft new cards or remove old ones.