Same as @mutedial, I often start with the schematic. Since I don’t actually fully understand them, I generally try to trace current flow through the schematic, find a point across which the voltage is as expected (power input is a good place to start), and then follow the schematic point by point until I find where the breakdown is happening. Or, if there’s a jack that’s not outputting, working backwards from there until you do have voltage.
Can you post decent quality photos of both sides of your board? Maybe one of us can see something you’re not seeing.
My personal points of failure tend to be ICs that I’ve mounted in the wrong orientation, and when doing SMD, caps that I’ve failed to solder correctly (it’s always caps for me).
Synthrotek has a bad name these days (and deservedly so, frankly). But, this set of troubleshooting steps for DIY builds is very good. https://www.synthrotek.com/tech/troubleshooting-your-build/