I’m assuming pre-patching only refers to patch cables?
I have so many modules that work with other types of connections, have the ability to save presets, or have normalled connections that it leaves a gray area for what it means to be pre-patched.
The Expert Sleepers ES-8 uses an ADAT cable to connect to the ES-6. The ES-6 is only usable with the ES-8 with that cable. The ES-8 is only usable as an audio interface with the USB cable connected.
Orthogonal Devices’ ER-301 is connected to a Monome Teletype via I2C in the back and preset saving is basic functionality for both modules. It’s interesting to think about unpatching a module with presets as wiping the presets before patching.
Pittsburgh Modular Lifeforms SV-1’s connections are normalled by default. So in a weird way it would require intentionally patching dummy cables into it in order for it to be non-pre-patched.
But to answer the question, I always leave the non-patch cables plugged in and remove all the other patch cables. For modules that have normalled connections I start without patch cables so I start with a normalled connection. For modules that have preset saving I start from a new preset, but I don’t wipe out existing presets.