I recently downsized from a 7U/84 HP case to a 4U/62 HP case (Intellijel Palette), i.e. quite similar in size to what youāre mentioning and my setup is based on a Teletype + a bunch of things that it can communicate with. I also have at least 3 (obvious) ways to get overdriven sounds, because this is something I like :). And I can make interesting things without using the TT at all, which is good in terms of versatility.
The 1U free space will likely be filled with a dual VCA, but Iām not certain yet.
One caveat about that setup though : the Teletype + backpack + i2c connections is a tight fit. The Telex expanders and W/ were also tight. It can fit but you have to be very careful with your power cables, so it works if you want an instrument that will not change much over time, more likely to be a pain if you plan on changing the TTās location all the time.