The Twister needs the editor app (Mac/Win). On the EC4 you just drop into the edit and setup modes on the unit itself.
If you have a generic base template on the Twister, every script has its own param sets so it’s not like mapping Awake means you can’t also map Oooooooo. Whichever script is active will be the active mapping.
I mean, if you’re just midi mapping the knobs as needed, don’t need specific CCs/Notes for a script, and you know where you want the special knob modes (EQ-style center detention, for example) —you still have 4 layers! Then it’s maybe no big deal.
The Twister also has better push-toggle and push-momentary features than the EC4. Handling different styles of encoder push is the EC4’s weakest spot (for me).