Yes - the native driver (I’m using El Capitan) loads when the grid is connected, and I can see serialosc processes also (but only when the grid is connected):
gravity:~ music$ ls -alt /dev | grep serial && ps auxw | grep serialosc
crw-rw-rw- 1 root wheel 18, 7 Aug 14 18:12 cu.usbserial-A4039N93
crw-rw-rw- 1 root wheel 18, 6 Aug 14 18:12 tty.usbserial-A4039N93
music 381 0.0 0.0 2453352 1136 ?? S 6:07PM 0:00.00 /Library/Application Support/Monome/serialosc.bundle/Contents/MacOS/serialosc-detector
music 373 0.0 0.0 2462796 956 ?? S 6:07PM 0:00.01 /Library/Application Support/Monome/serialosc.bundle/Contents/MacOS/serialoscd
Relevant console messages:
8/14/16 6:14:18.000 PM kernel[0]: AppleUSBFTDI: fInBufPool,kMaxInBufPool 8,64
8/14/16 6:14:18.000 PM kernel[0]: AppleUSBFTDI: Version number - 5.0.0, Input buffers 8, Output buffers 16
But would you expect this?
8/14/16 6:17:46.564 PM com.apple.xpc.launchd[1]: (org.monome.serialosc) Service only ran for 0 seconds. Pushing respawn out by 10 seconds.
8/14/16 6:17:56.581 PM com.apple.xpc.launchd[1]: (org.monome.serialosc) Service only ran for 0 seconds. Pushing respawn out by 10 seconds.
8/14/16 6:18:06.602 PM com.apple.xpc.launchd[1]: (org.monome.serialosc) Service only ran for 0 seconds. Pushing respawn out by 10 seconds.