I think if you set things up and it’s working well, then there’s no need to rearrange. If for some reason you’re noticing that I2C is inconsistent or not working, that could be one thing to troubleshoot.
For what it’s worth, my Teletype and Just Friends are one module away from being on opposite sides of my 104HP case, and the I2C works just fine, so I don’t think it’s a huge concern.