Michigan Synth Works has been using an I2C repeater chip in their F8R expander which effectively isolates the A- and B-side bus capacitance (usually two cases, or a case plus 16n, etc.). That kind of chip should help with stability but not with overcrowding.
I think we are approaching a time when an I2C router is a desired part of the ecosystem. But honestly I find myself happier when I separate my devices into multiple buses. That may be less of an option for those who lack multiple leader devices though.
I still am wishing for multiple addresses for JF. It should be a relatively simple matter to release an “address #2” version of the (closed-source) firmware. Trent was disinterested in the concept last time I asked but it can’t hurt to have more folks asking.