I’ve been using DipTrace for the last couple of years and have been pretty pleased with it. While Eagle might be better documented or have more libraries (which you can still use anyway in DipTrace) I’ve yet to run into something I can’t find a solution for, and it is a significant upgrade from Fritzing. Only irritating thing I have found is running it on a mac with Wine it doesn’t like the right click function on the track pad, I have to use an external mouse (which is easier for doing this kind of thing anyway…). Fritzing is really easy, especially if you want to drag and drop sparkfun parts and things like that, but its also so simple I found getting things done with it incredibly frustrating. If you are doing basic layouts the non-commercial use free version of DipTrace doesn’t limit you by board size, just the number of pins (300) and to two signal layers, which should be plenty for doing basic stuff. Beyond that you can buy versions again based on number of pins/signal layers needed rather than having to go all or nothing.
I’m working on my first panelized board which I’ll probably send out soon. Trying to get the whole mouse bite/router thing sorted so my bites give a clean break without indentations on the finished board, but I anticipate the first time I’m bound to make some sort of mistake.