(I realise that the thing I was referring to isn’t necessarily relevant - there were reasons in the thing I was doing I could chain things - but still using multiple repeating smaller units makes sense. (For a long while, monome grids were made out of 8x8 boards chained, for instance; I forget if they still are).)
regarding having ideas about what chips can do: don’t listen to garbled sunday afternoon chat from me on a forum - read a datasheet. That may well clarify what things should end up where in your design. Sometimes, it’s more important to thing with your hands. I
will definitely tell you that if you can make it work with one mux, adding more muxes is not hard at all. That means you can effectively prototype/play with an eight-pot controller before you go further.