I have done sample-based production with Cubase, Pro Tools, Reason, FL Studio, Logic and Ableton, and I find Ableton to be the best and easiest by a wide margin. It’s expensive and has a learning curve up front, but once you get the hang of it, everything else is like wearing oven mitts.
I acquire commercial sample packs and freebies off the web, but for artistic satisfaction, my favorite source for samples is my iTunes library. I’ve done so much sampling of my music library that I’ve trained myself to “spot” good samples effortlessly. Over time, I’ve evolved a complex folder hierarchy, set of file naming conventions and color-coding of frequently used breaks. I’d happily describe them to you, but it wouldn’t be very helpful, because your own system will have to reflect your particular needs. (For example, “Michael Jackson” and “James Brown” are top-level categories for me, on the same hierarchy level as “rock” and “jazz”, because I sample those two so much.) The library management aspect of sample-based music is as important to the creative process as any other musical or technical skill. You can think of it as an art medium unto itself rather than just a chore, but you have to do it.
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