I’m one of the rare creatures that doesn’t like Ableton, though that’s probably simply a matter of habit. I use Maschine, which works really well with samples IMHO… and even though I don’t actually work with samples that much anymore, and tend not to loop or even sequence most of the time… routing of I/O and effects channels is pretty good for my needs. Its main weakness now I think is you can’t use plugins to generate MIDI.
Maschine was originally meant as a sample-based drum machine, and then gained plugin hosting and slowly grew into more of a full fledged DAW. I like the workflow, having come from FL Studio before that. (I find FL a little bloated and inconsistent by comparison.)