I’m also going to chime in and recommend anything from MOTU, especially in their current AVB product line. I’m currently using an UltraLite mk4, which I bought for use while traveling based on my very positive experience with the MOTU 16A in my home studio. Both are super low latency, super clear AD/DA conversion, and the whole series has an excellent internal mixer and routing matrix. I personally only use the mixer to do gain balancing on analog inputs, but one place I think they both shine is that they can operate standalone without a PC, are freely routable, and can be networked to each other and pass channels between units. I actually don’t even need Soundflower anymore because I can just assign a sub mix to return to a couple virtual input channels and I have a freely available loopback device inputs for resampling or capturing various playback sources. I was also able to sell my large analog mixer, get rid of a nest of cables, free up a bunch of desk space, and stop being uncomfortably warm in my studio in the summer.
The latency and reliability of both interfaces also have a quality I find truly valuable: they make me forget they’re there.
Another nice feature is that you can also save different configurations for each section of the device (from global input trims and routing, down to individual mixer channel settings), or overall configurations for various use cases. My only complaint is that they boot slow, but I guess I can handle that given everything else they do exceptionally well.
Oh and for what it’s worth, I don’t find them nearly as ugly as most of the interfaces on the market. Nice blue LCD and black powder coated metal enclosure that feels like you could drop it off a moving vehicle and it would be just fine. Also comes with a rack mount kit.