Not sure if this is of use to you, but here’s my experience…
Just like with every other instrument you need to build up vocabulary to have control (if that’s desired), and because the Plumbutter is a semi-modular which means that the patch itself is part of the vocabulary and allows for new gestures (to learn).
For live shows I generally prepare and play one or two patches and do some minimal prepared patch programming on the spot, so I know the gestures/possibilities well for the patches and I’m able to play it with intent (which is sometimes important to me). After having used the Plumbutter for 4 years now I think know all it’s parts well, but some interconnections of parts lead to random behaviour (esp. interconnected rollz) which I would avoid using to patch program in a live context myself.
I’ve seen people using patch programming as part of the performance, building up a patch during the play. I always wonder how much of that is pre-scripted, plain mastery of the instrument or improv/exploration.