ok, not really rPI related … but I think @jasonw22 was asking about using a virtualbox?!
so the answer is yes, it can be made to work… Ive got it working under vmware 
I actually did all the Push2 dev for matron on Vmware Fusion (mac) hosting Ubuntu 18.04 (64bit) , but I didnt bother trying the audio till this evening (for fun, over a glass of wine)
‘as expected’ jack and the ‘virtual audio driver’ did not work… (Ive logged a support request)
so I went a different route, VMware has excellent usb support,
so I plugged in a portable USB audio interface (Zoom H5 in AI mode) , then gave it to vmware to host, told jack to use this - and viola, the lovely dulcet tones of Norms, using my Push 2 to control it all.
(no xruns or anything, so thats a bonus!)
why? - why not?
no, actually, its useful for development purposes, Ive got better tools on desktop Ubuntu, so its easier for me to try things there, get them working … git push them, then bring them down to the rPI for testing.
so if you want to try norns out on the desktop give it a whirl, as ive mentioned previously in this thread the norns documentation is really good.