…this sounds like the exact behavior I saw when a non-Apple FTDI driver was installed (I’ve also found the USB3 ports on the Mac Pro Late 2013 to be more finicky than any other machine I use).
To verify you are using the Apple driver and not something else:
- disconnect your grid and reboot the machine
- connect the grid, wait 5 seconds, and enter the following command in the terminal:
kextstat -l | grep -i ftdi
…the output should be one line which contains com.apple.driver.AppleUSBFTDI - if it doesn’t you have another FTDI driver installed. Find it, remove it, and reboot (see instructions above).
I’ve been using the Apple supplied FTDI driver and serialosc 1.4 on a Mac Pro 2013 under both 10.11 and 10.12 without issue.