An artist who I think really has honed in on this technique is Acriel, who works primarily in Pd making generative microtonal patches. I find that when I am hearing the chord as a cluster it is not so dissimilar from a heavily detuned subtractive synth patch, but with more nuance.
That puredata experiment is fascinating! Really wanna play around with this concept now!
To be unnecessarily specific, 8EDT is 5.04743802858EDO, 16EDT is 10.0948760571099EDO, and 25ED5 is 10.76691090999999EDO. Just a side fact. 
Yeah, a lot of people claim 8 EDT is basically equivalent to 5 EDO, but there is a definite audible difference in my ears, especially with wider leaps - plus, 8 EDT has those lovely “false octaves” which are slightly flat 
Hypothesis: hip-hop’s popularity is due in part to the inherent microtonality of rap melodies. http://www.ethanhein.com/wp/2016/visualizing-hip-hop-melodies/
That’s an interesting project. I’m not sure rap is inherently microtonal, anymore than natural speech is - I doubt anybody would consider the speech patterns of the average rapper to be part of the “melody”, and the same rap would be recognizable even if you spoke with different inflection/emphasis, even though you’d be technically “changing the melody”. There have been some very interesting explorations of the musicality of speech, however, my favorite being the classic “John Somebody” by Scott Johnson:
They end up converting the piece into a mostly 12-EDO framework, but it’s a very intriguing concept which is lots of fun to listen to!
Harry Partch also spent a lot of his career exploring the rhythms of natural human speech - it’s interesting how we are creating and learning these kinds of “songs” all the time and almost never notice it!
This thread inspired me to write a little toy tool to easily explore scales created from arbitrary frequencies …
This is a really cool tool! You should definitely expand on this, it’s a fun way to play around with different divisions of intervals and could definitely become a handy tool, especially if you made it so you could export your tunings in .scl files! 