An artist who I think really has honed in on this technique is Acriel, who works primarily in Pd making generative microtonal patches. I find that when I am hearing the chord as a cluster it is not so dissimilar from a heavily detuned subtractive synth patch, but with more nuance.
That puredata experiment is fascinating! Really wanna play around with this concept now!
To be unnecessarily specific, 8EDT is 5.04743802858EDO, 16EDT is 10.0948760571099EDO, and 25ED5 is 10.76691090999999EDO. Just a side fact. 
Yeah, a lot of people claim 8 EDT is basically equivalent to 5 EDO, but there is a definite audible difference in my ears, especially with wider leaps - plus, 8 EDT has those lovely âfalse octavesâ which are slightly flat 
Hypothesis: hip-hopâs popularity is due in part to the inherent microtonality of rap melodies. http://www.ethanhein.com/wp/2016/visualizing-hip-hop-melodies/
Thatâs an interesting project. Iâm not sure rap is inherently microtonal, anymore than natural speech is - I doubt anybody would consider the speech patterns of the average rapper to be part of the âmelodyâ, and the same rap would be recognizable even if you spoke with different inflection/emphasis, even though youâd be technically âchanging the melodyâ. There have been some very interesting explorations of the musicality of speech, however, my favorite being the classic âJohn Somebodyâ by Scott Johnson:
They end up converting the piece into a mostly 12-EDO framework, but itâs a very intriguing concept which is lots of fun to listen to!
Harry Partch also spent a lot of his career exploring the rhythms of natural human speech - itâs interesting how we are creating and learning these kinds of âsongsâ all the time and almost never notice it!
This thread inspired me to write a little toy tool to easily explore scales created from arbitrary frequencies âŠ
This is a really cool tool! You should definitely expand on this, itâs a fun way to play around with different divisions of intervals and could definitely become a handy tool, especially if you made it so you could export your tunings in .scl files! 