Might as well lay my cards on the table: I’m listening to Black Box’s “I Don’t Know Anybody Else” right now and the “hyuh” dude sample is cracking me up. It’s one of my favorite bad samples. Black Box is great for all those sounds you’re tired of, like the M1 piano is on pretty much every track. Of course, the M1 also gave us the organ that is all over early '90s Eurodance.
The other big synth of that time was the Roland D50 and a bunch of those presets are really famous, too. Like the pizz patch that Enya used on “Orinoco Flow.” (Hell, she pretty much ran a whole career off that synth.) The shakuhachi was on a bunch of stuff too.
We can’t forget the DX series – and TX81Z – and the millions of records they sold based on the Fulltines EP and Solid/Lately Bass patches. Almost as famous a bass sound as Alpha Juno Hoover bass.
Back to the “hyuh” dude: another vocal interjection that got beat up in the early '90s was a “whoop” sound. If you’ve ever heard a Praga Khan song, you know the one. The absolute best sample of all-time, though, is definitely the Emu II Loon. Oh yeah.
Famous drum machines or loops are less obviously bothersome to me because they just kinda are always are what they are. They’re bedrocks of genres. Maybe I shouldn’t say “bothersome” because I unironically love all these obvious corny sounds. 
What can you add to the list? I almost want to make a track with all the clichés in it. 
