@bradfromraleigh - I've been tinkering with this very idea, having a Twister and a somewhat DIY 128 setup (two 40hs - old school
Are you using monome apps in Live or straight Max patches?
Either way, it wouldn't be that hard to wire up support for the Twister. I was working on adapting the Mono Sequencer patch in Max for Live so that it used the monome as a control surface. I was using different pages to allow velocity (for example) to be set per step as well as the note, but you could equally well take input from the Twister into the coll that stores those values per step and output them as part of the MIDI note.
I got close to what I was looking for hacking on the Mono Sequencer, but it was getting messy, and I really wanted to just use the monome with my modular without having to boot up Live etc. etc. My DIY grid setup means Whitewhale isn't an option - hence I'm currently taking what I learnt from the Max for Live attempt and jumping across to python on a Raspberry Pi as something that can be more or less dedicated to just running a monome sequencer for the modular.
In any case, if you want to have a go at adding Twister support, I'd be happy to share my Mono Sequencer hacks - it was never solid enough to post back on maxforlive.com but I don't mind sharing with those who are interested.